Abstract: With the continuous deepening of local theories and the extensive attention to individual well-being, the relationship between place and well-being has become an issue worthy of in-depth discussion by academic circles. How to improve the well-being of tourists in tourism and build the local significance of the destination is of great significance to the sustainable development of tourism. This article, by taking J ieshi Mountain in Changli County, Hebei Province, as an example, explores the relationship between the place meaning of tourist destinations and the well-being of tourists. Starting from the place meaning of natural ecology, historical culture, leisure and recreation, and emotional identity, this article probes into the implications for the well-being of tourists from such five perspectives as physical and mental health, environment and safety, interpersonal relationships, knowledge development and infrastructure, and builds a preliminary model of the impact of place meaning on the well-being of tourists. Through the research results, we aim at putting forward corresponding suggestions for local tourism management and development, creating and tapping place meanings, and improving the well-being of tourists.